Characterization of urinary steroids in adrenal hyperplasia: isolation of metabolites of cortisol, compound S, and desoxycorticosterone from a normotensive patient with adrenogenital syndrome.

Congenital virilizing adrenal hyperplasia miiay present a varied clinical picture. Patients have been described who have only excessive virilization (1); others have an associated Addison-like electrolyte disturbance (2, 3), with hypoglycemia (4), or with hypertension (5-9). Recent studies (1012) indicate that the manifestation of virilism may result from defects in the biosynthesis of cortisol.' The first suggestion regarding the nature of the error was made by Lewis and Wilkins (12), and